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CEM high-throughput microwave synthesizer
The CEM high-throughput microwave peptide synthesizer is an advanced microwave peptide synthesis platform. It has revolutionary one pot coupling and d
Product details
CEM microwave synthesizer, CEM high-throughput microwave peptide synthesizerIt is an advanced microwave peptide synthesis platform. It has revolutionary one pot coupling and deprotection technology, which can achieve a synthesis scale of 0.1mmol, with each cycle taking only 2.5 minutes and only 10mL of waste liquid per cycle. Realize more stable manufacturing of purer, more difficult, and longer complex peptides.
Characteristics of CEM high-throughput microwave peptide synthesizer:
1. It only takes 45 minutes to synthesize a single 20mer peptide fragment;
2. It only takes 20 hours to synthesize 24 peptides (20 mers) per batch, resulting in only 4.5 liters of total waste liquid;
3. Significantly reduce the use of solvents and deprotection agents;
4. Cancel the step of discharging after coupling to shorten the cycle time.
Faster, more efficient, and more cost-effective
Complete the cycle in 4 minutes
Save 90% of reagent consumption
The purity has been increased to an average of over 70%
CEM microwave synthesizerTechnical parameters:
1. Single synthesis interval: 0.005-5mmol;
2. Reactor specifications: three types of reactors;
3. Chemical method: Fmoc；
4. Amino acid reserve: In situ activator automatically adds 30 natural amino acids, can add 7 spare rare amino acids or reagents, and supports up to 120ml bottles;
5. Temperature measurement: In situ optical fiber for more accurate measurement of internal temperature;
6. Fluid measurement: Flex Add technology for simultaneous transfer of amino acids, activators, activator bases, as well as transfer measurement of main solvents and deprotection reagents;
7. Mixing method: Inert gas bubbling mixing;
8. Waste liquid container: 1L and overflow detection;
9. LED indicator: displays the system's working status and operational assistance;
10. Control mode: Laptop (wireless optional);
11. Optional accessories: UV monitoring module, HT high-throughput resin filling machine, peptide lysis module;
12. Report creation: Create logs for each step of the PDF method file.
Product benefits:
1. PowerMAX Circular Focused Single Mode Microwave Technology:
The foundation and technical indicators of third-generation microwave chemical kinetics. High precision energy regulation and excellent quantitative coupling potential well effect have ultimately achieved an efficient and precise single-mode platform, which extends the traditional standing wave 30 mL single-mode to 300 mL, achieving a leap in quantity and quality, and laying the foundation for the position of similar single-mode microwaves.
2.Liberty uses a one pot coupling and deprotection process:
This technology involves adding deprotection reagents (bases) directly to a non draining post coupling mixture. CEM is based on the following research findings: faster reaction kinetics in the liquid phase promote rapid hydrolysis or self condensation of active esters, thereby avoiding potential side reactions at the amino functional groups bound to the resin. Then, Fmoc removal is carried out continuously at high temperatures. Optimize the reagent dosage to produce a substantially neutral reaction mixture at the end of the deprotection step.
3. Headspace Flushing - Cleaning the reactor surface:
A new feature of the Liberty Blue 2.0 and Liberty PRIME 2.0 systems is the use of headspace flushing to provide a cleaner reactor surface, protecting it from the effects of volatile deprotection bases at high temperatures. The "headspace flushing" technology helps synthesize longer peptides and achieve ideal purity levels by ensuring the cleanliness of the reactor surface.
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